索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]李 妍 蔡晓波 陆伦根.脂肪性肝病动物模型研究进展[J].国际消化病杂志,2019,03:157-161.
点击复制

脂肪性肝病动物模型研究进展(PDF)

《国际消化病杂志》[ISSN:1673-534X/CN:31-1953/R]

期数:
2019年03期
页码:
157-161
栏目:
脂肪肝和肝纤维化专题综述
出版日期:
2019-06-25

文章信息/Info

Title:
-
作者:
李 妍 蔡晓波 陆伦根
200080 上海交通大学附属第一人民医院消化科
Author(s):
-
关键词:
脂肪性肝病 酒精性脂肪性肝病 非酒精性脂肪性肝病 动物模型
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-534X.2019.03.004
文献标识码:
-
摘要:
脂肪性肝病是较为常见的慢性肝病,早期可仅表现为肝脂肪变性,随病情进展可渐次发展为炎性反应、肝纤维化甚至肝硬化、肝细胞癌。根据患者是否有过量饮酒史,脂肪性肝病可分为酒精性脂肪性肝病(AFLD)和非酒精性脂肪性肝病(NAFLD)。构建脂肪性肝病动物模型对于研究脂肪性肝病的发病机制及诊治方法至关重要。近年来脂肪性肝病的研究蓬勃发展,现有动物模型均能部分模拟脂肪性肝病的发病,但不能完全复制其临床特点及病理生理学变化。该文对目前脂肪性肝病动物模型构建方案作一综述,为脂肪性肝病研究提供参考。
Abstract:
-

参考文献/References

1 赵静波, 王泰龄, 张晶, 等. 大鼠急性酒精性肝损伤模型分析[J]. 中日友好医院学报, 1996, 10(1): 17-20.
2 苗明三, 康乐, 方晓艳, 等. 酒精性肝损伤动物模型制备规范(草案)[J]. 中华中医药杂志, 2018, 33(3): 1000-1003.
3 Mathews S, Xu M, Wang H, et al. Animals models of gastrointestinal and liver diseases. Animal models of alcohol-induced liver disease: pathophysiology, translational relevance, and challenges[J]. Am J Physiol Gastrointest Liver Physiol, 2014, 306(10): G819-G823.
4 Shukla SD, Pruett SB, Szabo G, et al. Binge ethanol and liver: new molecular developments[J]. Alcohol Clin Exp Res, 2013, 37(4): 550-557.
5 Chen P, Miyamoto Y, Mazagova M, et al. Microbiota protects mice against acute alcohol-induced liver injury[J]. Alcohol Clin Exp Res, 2015, 39(12): 2313-2323.
6 Howarth DL, Passeri M, Sadler KC. Drinks like a fish: using zebrafish to understand alcoholic liver disease[J]. Alcohol Clin Exp Res, 2011, 35(5): 826-829.
7 戴文聪. 急性酒精性脂肪肝斑马鱼模型的建立及异甘草酸镁保肝作用机制研究[D]. 南方医科大学, 2013.
8 Best CH, Hartroft WS, Lucas CC, et al. Liver damage produced by feeding alcohol or sugar and its prevention by choline[J]. Br Med J, 1949, 2(4635): 1002-1006.
9 Lieber CS, DeCarli LM, Sorrell MF. Experimental methods of ethanol administration[J]. Hepatology, 1989, 10(4): 501-510.
10 曾涛, 姜璐璐, 张翠丽, 等. 两种Lieber-DeCarli液体饲料诱导的小鼠酒精性肝损伤模型的建立[J]. 毒理学杂志, 2012, 26(4): 258-262.
11 Liangpunsakul S, Rahmini Y, Ross RA, et al. Imipramine blocks ethanol-induced ASMase activation, ceramide generation, and PP2A activation, and ameliorates hepatic steatosis in ethanol-fed mice[J]. Am J Physiol Gastrointest Liver Physiol, 2012, 302(5): G515-G523.
12 Bertola A. Rodent models of fatty liver diseases[J]. Liver Research, 2018(2): 3-13.
13 郭跃东, 马丽杰. 酒精性肝损伤动物模型研究进展[J]. 内蒙古医学杂志, 2016, 48(3): 304-306.
14 Tsukamoto H, French SW, Benson N, et al. Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet[J]. Hepatology, 1985, 5(2): 224-232.
15 高斌, 常彬霞, 徐明江. 慢性酒精喂养加急性酒精灌胃的酒精性肝病小鼠模型(NIAAA模型或Gao-Binge模型)[J]. 传染病信息, 2013, 26(5): 307-311.
16 Bertola A, Park O, Gao B. Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: a critical role for E-selectin[J]. Hepatology, 2013, 58(5): 1814-1823.
17 Petrasek J, Bala S, Csak T, et al. IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice[J]. J Clin Invest, 2012, 122(10): 3476-3489.
18 Iracheta-Vellve A, Petrasek J, Gyogyosi B, et al. Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice[J]. Liver Int, 2017, 37(7): 968-973.
19 Hebbard L, George J. Animal models of nonalcoholic fatty liver disease[J]. Nat Rev Gastroenterol Hepatol, 2011, 8(1): 35-44.
20 Machado MV, Michelotti GA, Xie G, et al. Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease[J]. PLoS One, 2015, 10(5): e0127991.
21 Larter CZ, Yeh MM, Williams J, et al. MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes[J]. J Hepatol, 2008, 49(3): 407-416.
22 王振, 杨涛, 李世朋, 等. 脂肪肝动物模型研究进展[J]. 实用器官移植电子杂志, 2016, 4(2): 105-108.
23 Romestaing C, Piquet MA, Bedu E, et al. Long term highly saturated fat diet does not induce NASH in Wistar rats[J]. Nutr Metab(Lond), 2007, 4: 4.
24 Ito M, Suzuki J, Tsujioka S, et al. Longitudinal analysis of murine steatohepatitis model induced by chronic exposure to high-fat diet[J]. Hepatol Res, 2007, 37(1): 50-57.
25 Yimin, Furumaki H, Matsuoka S, et al. A novel murine model for non-alcoholic steatohepatitis developed by combination of a high-fat diet and oxidized low-density lipoprotein[J]. Lab Invest, 2012, 92(2): 265-281.
26 Ogasawara M, Hirose A, Ono M, et al. A novel and comprehensive mouse model of human non-alcoholic steatohepatitis with the full range of dysmetabolic and histological abnormalities induced by goldthioglucose and a high-fat diet[J]. Liver Int, 2011, 31(4): 542-551.
27 Fujii M, Shibazaki Y, Wakamatsu K, et al. A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma[J]. Med Mol Morphol, 2013, 46(3): 141-152.
28 张程亮, 贺雯茜, 徐艳娇, 等. 果糖诱导非酒精性脂肪性肝病小鼠动物模型的构建和评价[J]. 肝脏, 2017, 22(8): 700-704.
29 Tetri LH, Basaranoglu M, Brunt EM, et al. Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent[J]. Am J Physiol Gastrointest Liver Physiol, 2008, 295(5): G987-G995.
30 Clapper JR, Hendricks MD, Gu G, et al. Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment[J]. Am J Physiol Gastrointest Liver Physiol, 2013, 305(7): G483-G495.
31 刘仁淼. 全胃肠外营养致肝脏损伤的研究[J]. 内蒙古中医药, 2013, 32(15): 60.
32 梁力建, 罗时敏, 郑进方, 等. 肉毒碱治疗TPN大鼠肝脂肪变性的研究[J]. 中华外科杂志, 1999(8): 51-53, 64.
33 Trak-Smayra V, Paradis V, Massart J, et al. Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie diet[J]. Int J Exp Pathol, 2011, 92(6): 413-421.
34 Hummel KP, Dickie MM, Coleman DL. Diabetes, a new mutation in the mouse[J]. Science, 1966, 153(3740): 1127-1128.
35 Sanches SC, Ramalho LN, Augusto MJ, et al. Nonalcoholic steatohepatitis: A search for factual animal models[J]. Biomed Res Int, 2015, 2015: 574832.
36 武丽. Alstrom综合征临床研究进展[J]. 世界最新医学信息文摘, 2019, 19(30): 103-104.
37 Farrell GC, Mridha AR, Yeh MM, et al. Strain dependence of diet-induced NASH and liver fibrosis in obese mice is linked to diabetes and inflammatory phenotype[J]. Liver Int, 2014, 34(7): 1084-1093.

备注/Memo

备注/Memo:
作者单位: 200080 上海交通大学附属第一人民医院消化科
通信作者: 陆伦根,Email: lungenlu1965@163.com
更新日期/Last Update: 2019-06-25