«上一篇/Previous Article|本期目录/Table of Contents|下一篇/Next Article»

《国际消化病杂志》[ISSN:1673-534X/CN:31-1953/R]

期数:

2024年06期

页码:

376-380，386

栏目:

论著

出版日期:

2024-12-20

文章信息/Info

Title:

Relationship between serum levels of zonulin and Omentin-1 and the severity and prognosis of ulcerative colitis in patients

作者:

陈伟丽; 史利斌; 王 艳; 祖 喆; 高文侠; 刘 尧; 王建桥; 于 倩

063000 唐山市中医医院肛肠科（陈伟丽、祖喆），超声科（史利斌），药剂科（王艳、高文侠），肿瘤科（于倩）；063000 河北唐山，开滦总医院药剂科（刘尧）；064300 河北唐山，迁西县中医院内科（王建桥）

Author(s):

CHEN Weili;  ZU Zhe; SHI Libin; WANG Yan;  GAO Wenxia; YU Qian; LIU Yao; WANG Jianqiao

CHEN Weili, ZU Zhe. Department of Anorectal, Tangshan Hospital of Traditional Chinese Medicine, Tangshan 063000, China; SHI Libin. Department of Ultrasound, Tangshan Hospital of Traditional Chinese Medicine, Tangshan 063000, China; WANG Yan, GAO Wenxia. Department of Pharmacy, Tangshan Hospital of Traditional Chinese Medicine, Tangshan 063000, China; YU Qian. Department of Oncology, Tangshan Hospital of Traditional Chinese Medicine, Tangshan 063000, China;LIU Yao. Department of Pharmacy, Kailuan General Hospital, Tangshan 063000, China; WANG Jianqiao. Department of Internal Medicine, Qianxi Hospital of Traditional Chinese Medicine, Tangshan 064300, China

关键词:

溃疡性结肠炎; 连蛋白; 血清网膜素-1; 病情严重程度; 预后

Keywords:

Ulcerative colitis;  Zonulin;  Serum Omentin-1;  Severity of disease;  Prognosis

分类号:

-

DOI:

10.3969/j.issn.1673-534X.2024.06.006

文献标识码:

-

摘要:

目的探讨血清连蛋白（zonulin）和网膜素-1（Omentin-1）与溃疡性结肠炎（UC）患者病情严重程度及预后的关系。方法选择2020年9月至2022年12月在唐山市中医医院就诊的93例活动期UC患者设为UC组，并根据病情严重程度将UC患者分为轻度UC组（n＝38）、中度UC组（n＝33）和重度UC组（n＝22），根据预后情况分为预后良好组（n＝61）和预后不良组（n＝32）。另选择同期来该院的90名健康体检者设为对照组。采用ELISA法检测各组的血清zonulin和Omentin-1水平。采用ROC曲线分析血清zonulin和Omentin-1对UC患者预后不良的预测价值。采用多因素logistic回归分析探讨UC患者预后不良的影响因素。结果UC组的血清zonulin水平显著高于对照组，血清Omentin-1水平显著低于对照组（P均＜0.05）。重度UC组的血清zonulin水平分别显著高于中度UC组和轻度UC组，血清Omentin-1分别显著低于中度UC组和轻度UC组（P均＜0.05）；中度UC组的血清zonulin水平显著高于轻度UC组，血清Omentin-1水平显著低于轻度UC组（P均＜0.05）。预后不良组的血清zonulin和C反应蛋白（CRP）水平均显著高于预后良好组，血清Omentin-1水平显著低于预后良好组（P均＜0.05）。血清zonulin、Omentin-1单独及联合预测UC患者预后不良的AUC分别为0.779、0.775和0.877。血清zonulin是UC患者预后不良的危险因素，而血清Omentin-1则是UC患者预后不良的保护因素（P均＜0.05）。结论血清zonulin和Omentin-1与UC患者的病情严重程度及预后均密切相关，两者均有潜力作为UC患者病情评估及预后预测的标志物。

Abstract:

Objective? This paper intends to explore the relationship between serum levels of zonulin and Omentin-1 and the severity and prognosis of ulcerative colitis (UC) in patients. Methods? A total of 93 active UC patients treated at Tangshan Hospital of Traditional Chinese Medicine from September 2020 to December 2022 were selected as the UC group. These patients were divided into the mild group (n＝38), the moderate group (n＝33), and the severe group (n＝22) based on the severity of disease. They were further divided into a good prognosis group (n＝61) and a poor prognosis group (n＝32) based on prognosis. Additionally, 90 healthy individuals who visited the hospital during the same period were selected as the control group. ELISA method was used to detect the levels of serum zonulin and Omentin-1 in each group. ROC curve analysis was performed to assess the predictive value of serum zonulin and Omentin-1 for poor prognosis in UC patients. Multiple logistic regression analysis was conducted to explore factors influencing poor prognosis in UC patients. Results? The serum zonulin level in the UC group is significantly higher than that in the control group, while the serum Omentin-1 level is significantly lower (P＜0.05). The serum zonulin level in the severe group are significantly higher than those in the moderate and mild groups, while the serum Omentin-1 level is significantly lower (P＜0.05). The serum levels of zonulin and C-reactive protein (CRP) in the poor prognosis group are significantly higher than those in the good prognosis group, while the serum level of Omentin-1 is significantly lower (P＜0.05). The AUC for serum zonulin and Omentin-1, and their combination in predicting poor prognosis in UC patients are 0.779, 0.775, and 0.877, respectively. Serum zonulin is identified as a risk factor for poor prognosis in UC patients, while serum Omentin-1 is a protective factor (P＜0.05). Conclusion? Serum levels of zonulin and Omentin-1 are closely related to the severity and prognosis of UC patients. Both biomarkers have potential in evaluating the condition and predicting prognosis in UC patients.

参考文献/References

1 路敏敏, 王俊, 孙振林, 等. 血清miR-590联合粪便钙卫蛋白对溃疡性结肠炎的诊断价值及其与内镜下疾病活动度的相关性[J].国际消化病杂志, 2024, 44(3): 196-199.
2Liu D, Saikam V, Skrada KA, et al. Inflammatory bowel disease biomarkers[J]. Med Res Rev, 2022, 42(5): 1856-1887.
3 王建刚, 胡宜涛, 杨兰艳. 肠易激综合征病人血清连蛋白、单核细胞趋化蛋白-1水平与肠道菌群、炎症反应及胃肠症状严重程度的相关性[J]. 安徽医药, 2022, 26(5): 937-941.
4Caviglia GP, Dughera F, Ribaldone DG, et al. Serum zonulin in patients with inflammatory bowel disease: a pilot study[J]. Minerva Med, 2019, 110(2): 95-100.
5 崔海随, 胡德献, 杨昌立, 等. 急性脑出血患者血清MPO、S100A12、Omentin-1表达与神经功能损伤及预后的相关性[J].国际检验医学杂志, 2022, 43(18): 2223-2227.
6 中华医学会消化病学分会炎症性肠病学组, 钱家鸣, 吴开春. 炎症性肠病诊断与治疗的共识意见（2018 年，北京）[J]. 中国消化杂志, 2018, 38(5): 292-311.
7 魏国丽, 郑学宝, 周宇, 等. 参苓白术散联合美沙拉嗪治疗脾胃气虚型溃疡性结肠炎疗效及其对血清IL-17、TNF-α及IL-23水平的影响[J]. 广东医学, 2013, 34(1): 143-145.
8 叶玉兰, 胡彤, 徐丽娟, 等. 血浆白细胞介素9对生物制剂治疗后炎性肠病患者黏膜愈合的诊断及评估价值[J]. 中华医学杂志, 2023, 103(19): 1483-1489.
9 王蓉, 周玉霞, 姚晓文, 等. 生物标志物在溃疡性结肠炎中的应用研究进展[J]. 中国医刊, 2023, 58(1): 23-27.
10 杨姗, 穆兰芳, 陈玉芬, 等. 血清zonulin、GPC3与妊娠期肝内胆汁淤积症患者不良妊娠结局的关系[J]. 国际检验医学杂志, 2023, 44(5): 536-540, 547.
11 Gasaly N, de Vos P, Hermoso MA. Impact of bacterial metabolites on gut barrier function and host immunity: A focus on bacterial metabolism and its relevance for intestinal inflammation[J]. Front Immunol, 2021, 12: 658354.
12 Sturgeon C, Fasano A. Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases[J]. Tissue Barriers, 2016, 4(4): e1251384.
13 Kushlinskii NE, Gershtein ES, Zybina NN, et al. Blood serum zonulin in colorectal cancer, autoimmune bowel diseases, and irritable bowel syndrome[J]. Bull Exp Biol Med, 2022, 173(3): 376-379.
14 Riviere AJ, Smith KS, Schaberg MN, et al. Plasma and fecal zonulin are not altered by a high green leafy vegetable dietary intervention:secondary analysis of a randomized control crossover trial[J]. BMC Gastroenterol, 2022, 22(1): 184.
15 潘红艳, 李爱萍, 李强. 脂肪因子Omentin-1与肿瘤相关性的研究[J]. 实用肿瘤学杂志, 2021, 35(3): 282-286.
16 Genre F, Rueda-Gotor J, Remuzgo-Martínez S, et al. Omentin:a biomarker of cardiovascular risk in individuals with axial spondyloarthritis[J]. Sci Rep, 2020, 10(1): 9636.
17 Tao M, Yan W, Chen C, et al. Omentin-1 ameliorates experimental inflammatory bowel disease via Nrf2 activation and redox regulation[J]. Life Sci, 2023, 328: 121847.
18 Yin J, Hou P, Wu Z, et al. Decreased levels of serum omentin-1 in patients with inflammatory bowel disease[J]. Med Sci Monit, 2015, 21: 118-122.
19 Ma L, Zhang X, Zhang C, et al. Omentin-1 attenuates inflammation and barrier damage in DSS-induced ulcerative colitis in mice by inhibiting endoplasmic reticulum stress[J]. Gen Physiol Biophys, 2022, 41(3): 221-230.

备注/Memo

备注/Memo:

基金项目 ：河北省中医药类科学研究课题计划项目（2023196）
通信作者：于倩，Email: e34zhz@163.com

常用功能

更新日期/Last Update: 2024-12-20