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[1]计亦旻 胡晔东 徐 文 刘雁冰 孙 燕 刘 菲.无效食管动力在胃食管反流病中作用的探讨[J].国际消化病杂志,2018,03:187-190.
　JI Yimin HU Yedong,XU Wen,LIU Yanbing,et al.Potential role of ineffective esophageal motility in pathogenesis of gastroesophageal reflux disease[J].International Journal of Digestive Disease,2018,03:187-190.
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无效食管动力在胃食管反流病中作用的探讨(PDF)

《国际消化病杂志》[ISSN:1673-534X/CN:31-1953/R]

期数:
2018年03期
页码:
187-190
栏目:
论著
出版日期:
2018-06-25

文章信息/Info

Title:
Potential role of ineffective esophageal motility in pathogenesis of gastroesophageal reflux disease
作者:
计亦旻 胡晔东 徐 文 刘雁冰 孙 燕 刘 菲
200092 上海交通大学医学院附属新华医院急诊科(计亦旻); 200120 上海,同济大学附属东方医院消化科(胡晔东、徐文、刘雁冰、孙燕、刘菲)
Author(s):
JI Yimin;  HU Yedong;  XU Wen;  LIU Yanbing;  SUN Yan;  LIU Fei
Department of Emergency, Xinhua Hospital Affiliated to School of Medicine, Shanghai Jiao Tong University, Shanghai(200092), China; Department of Gastroenterology, East Hospital Affiliated to Tongji University, Shanghai(200120), China
关键词:
胃食管反流病;  无效食管动力;  食管动力障碍
Keywords:
Gastroesophageal reflux disease;  Ineffective esophageal motility;  Esophageal motility disorders
分类号:
-
DOI:
10.3969/j.issn.1673-534X.2018.03.009
文献标识码:
-
摘要:
目的 探讨无效食管动力(IEM)在胃食管反流病(GERD)发病中的作用。方法 选取2014年7月至2016年2月在上海同济大学附属东方医院就诊的GERD患者,所有患者均接受高分辨率(HRM)食管测压和24 h动态pH监测,排除食管-胃连接处(EGJ)压力和(或)形态异常的情况,共纳入49例GERD患者。根据HRM测压下食管远端收缩积分(DCI)将GERD患者分为IEM组、异常动力组和正常动力组。比较各组间食管动力及反流情况。结果 49例GERD患者中,IEM组19例,异常动力组15例,正常动力组15例。IEM组中反流性食管炎所占比例显著高于异常动力组和正常动力组(P<0.05),正常动力组与异常动力组相比较差异无统计学意义。IEM组平均吞咽DCI显著低于异常动力组及正常动力组(P<0.01),异常动力组显著低于正常动力组(P<0.01)。IEM组食管体部蠕动中断长度相较于异常动力组及正常动力组显著延长(P<0.01),异常动力组较正常动力组显著延长(P<0.01)。各组间酸反流次数、弱酸反流次数、非酸反流次数和总反流次数比较差异无统计学意义。IEM组DeMeester得分及合计酸反流时间较异常动力组及正常动力组显著增加,差异有统计学意义(P<0.05),异常动力组及正常动力组DeMeester得分及合计酸反流时间比较差异无统计学意义。49例GERD患者中,平均吞咽DCI与食管蠕动中断长度呈负相关(P<0.01),平均吞咽DCI与合计酸反流时间呈负相关(P<0.01)。结论 GERD患者中食管动力障碍与酸反流相关,食管体部收缩力度减弱,蠕动中断延长,与酸反流严重程度相关。IEM患者食管收缩力度较弱,酸反流时间较长,更易导致食管炎发生。
Abstract:
Objective This paper intents to explore the potential role of ineffective esophageal motility(IEM)in the pathogenesis of gastroesophageal reflux disease(GERD).Methods The GERD patients of East Hospital affiliated to Tongji University from July 2014 to Feb

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备注/Memo

备注/Memo:
基金项目:上海市卫生和计划生育委员会科研课题(201440307)
作者单位:200092 上海交通大学医学院附属新华医院急诊科(计亦旻); 200120 上海,同济大学附属东方医院消化科(胡晔东、徐文、刘雁冰、孙燕、刘菲)
通信作者:刘菲,Email: liufeiguo2010@163.com
更新日期/Last Update: 2018-06-25