|本期目录/Table of Contents|

[1]冯佳丽 贺 琼 胡辉忠.异黏蛋白和Wnt5b在乙型肝炎相关性肝细胞癌组织中的表达和意义[J].国际消化病杂志,2018,03:200-204.
　FENG Jiali,HE Qiong,HU Huizhong.Expression of MTDH and Wnt5b in patients with HBV-related hepatocellular carcinoma and its clinical significance[J].International Journal of Digestive Disease,2018,03:200-204.
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异黏蛋白和Wnt5b在乙型肝炎相关性肝细胞癌组织中的表达和意义(PDF)

《国际消化病杂志》[ISSN:1673-534X/CN:31-1953/R]

期数:
2018年03期
页码:
200-204
栏目:
论著
出版日期:
2018-06-25

文章信息/Info

Title:
Expression of MTDH and Wnt5b in patients with HBV-related hepatocellular carcinoma and its clinical significance
作者:
冯佳丽 贺 琼 胡辉忠
430015 武汉市红十字会医院消化科
Author(s):
FENG Jiali;  HE Qiong;  HU Huizhong
Department of Gastroenterology, Wuhan Red Cross Hospital, Wuhan(430015), China
关键词:
乙肝相关性肝癌;  异黏蛋白;  Wnt5b;  预后
Keywords:
HBV-related hepatocellular carcinoma;  MTDH;  Wnt5b;  Prognosis
分类号:
-
DOI:
10.3969/j.issn.1673-534X.2018.03.012
文献标识码:
-
摘要:
目的 探究异黏蛋白(MTDH)和Wnt5b在乙型肝炎相关性肝细胞癌(HCC)组织中的表达以及临床意义。方法 收集124例于2010年3月至2015年9月确诊为乙型肝炎相关性HCC患者的肿瘤组织和癌旁组织,免疫组织化学法检测MTDH和Wnt5b在HCC组织和癌旁组织中表达情况,从基因层面检测它们在两种组织中的表达,并分析其与临床病理之间的关系。结果 乙型肝炎相关性HCC组织中MTDH和Wnt5b的阳性表达率分别为68.55%和57.26%,癌旁组织中两者的阳性表达率分别为26.61%和22.58%,MTDH和Wnt5b在乙型肝炎相关性HCC组织中的表达明显升高,差异有统计学意义(P<0.05); MTDH和Wnt5b在乙型肝炎相关性HCC组织中的表达呈正相关(r=0.502,P<0.05); MTDH和Wnt5b在乙型肝炎相关性HCC组织中的表达水平与TNM分期(P=0.036)、BCLC分期(P=0.005)、淋巴结转移(P=0.026)、是否复发(P=0.005)有明显的相关性; MTDH和Wnt5b低表达组的术后生存时间均明显高于MTDH和Wnt5b高表达组,差异均存在统计学意义(P均<0.000 1)。结论 MTDH和Wnt5b在乙型肝炎相关性HCC组织中高表达,高表达的患者预后较差。
Abstract:
Objective This paper intends to explore the expression and clinical significance of MTDH and Wnt5b in patients with HBV-related hepatocellular carcinoma.Methods The carcinoma tissue and the paracancerous tissue of 124 cases with HBV-related hepatocellular

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备注/Memo

备注/Memo:
作者单位:430015 武汉市红十字会医院消化科
更新日期/Last Update: 2018-06-25