«上一篇/Previous Article|本期目录/Table of Contents|下一篇/Next Article»

《国际消化病杂志》[ISSN:1673-534X/CN:31-1953/R]

期数:

2024年03期

页码:

175-179,210

栏目:

论著

出版日期:

2024-06-25

文章信息/Info

Title:

Effect of Clostridium butyricum capsule combined with itopride on gastrointestinal hormones in patients with functional dyspepsia?

作者:

李双; 李颖; 谢菲

710077 陕西西安，西电集团医院药剂科（李双、谢菲）, 710068 陕西西安，陕西省人民医院腔镜中心（李颖）

Author(s):

LI Shuang;  XIE Fei; LI Ying

LI Shuang, XIE Fei. Department of Pharmacy, Xidian Group Hospital, Xi'an 710077, China; LI Ying. Department of Center of Endoscope, Shaanxi Provincial People's Hospital, Xi'an 710068, China

关键词:

酪酸梭菌活菌胶囊; 伊托必利; 功能性消化不良; 胃肠激素

Keywords:

Clostridium butyricum capsule;  Itopride;  Functional dyspepsia;  Gastrointestinal hormone

分类号:

-

DOI:

10.3969/j.issn.1673-534X.2024.03.008

文献标识码:

-

摘要:

目的探究酪酸梭菌活菌胶囊联合伊托必利对功能性消化不良（FD）患者的疗效及胃肠激素的影响。方法选择2021年11月至2022年12月西电集团医院收治的82例FD患者作为研究对象，采用随机数表法将患者分为观察组和对照组，每组各41例。对照组口服盐酸伊托必利治疗，观察组在此基础上口服酪酸梭菌活菌胶囊治疗，所有患者均连续治疗3个月。分别采用7分整体症状量表（GOSS）和功能性消化不良生存质量量表（FDDQL）评估2组治疗前后的临床症状和生活质量。采用放射免疫分析法检测血清促胃泌素（GAS）、5-羟色胺（5-HT）和胃动素（MLT）水平。比较2组治疗3个月后的临床有效率。结果与同组治疗前相比，治疗3个月后2组的GOSS评分和5-HT水平均降低，而FDDQL评分、GAS和MLT水平均升高，差异均有统计学意义（P均＜0.05）。治疗3个月后，观察组的GOSS评分和5-HT水平均低于对照组，而FDDQL评分、GAS和MLT水平均高于对照组，差异均有统计学意义（P均＜0.05）。治疗3个月后，观察组的临床有效率为95.12%，显著高于对照组（78.05%），差异有统计学意义（P＜0.05）。结论酪酸梭菌活菌胶囊联合伊托必利可有效缓解FD患者的消化道症状，促进胃肠蠕动功能恢复并提高临床疗效，有利于提高FD患者的生活质量，具有一定的临床推广价值。

Abstract:

Objective? This paper intends to investigate the effect of Clostridium butyricum capsule combined with itopride on gastrointestinal hormones in patients with functional dyspepsia (FD). Methods? A total of 82 FD patients who were admitted to Xidian Group Hospital from November 2021 to December 2022 were randomly assigned to the observation group (n＝41) and the control group (n＝41). The control group was treated with itopride hydrochloride, while the observation group was treated with Clostridium butyricum capsule combined with itopride hydrochloride. All patients were treated continuously for 3 months. The 7-score global symptom scale (GOSS) and functional digestive disorder quality of life scale (FDDQL) were used to evaluate the clinical symptoms and quality of life before and after treatment. The expression levels of serum gastrin (GAS), 5-hydroxytryptamine (5-HT), and motilin (MLT) were detected by using the radioimmunoassay method. The clinical effective rates of the two groups after 3 months treatment were compared. Results? After 3 months of treatment, the scores of GOSS and the levels of 5-HT in both groups decrease, while the scores of FDDQL, and the levels of GAS and MLT increase, with statistically significant differences (P＜0.05). After 3 months of treatment, the scores of GOSS and the levels of 5-HT in the observation group are lower than those in the control group, while the scores of FDDQL, and the levels of GAS and MLT are higher than those in the control group, with statistically significant differences (P＜0.05). After 3 months of treatment, the clinical effective rate of the observation group is 95.12%, which is higher than that of the control group (78.05%) , with a statistically significant difference (P＜0.05). Conclusions? Clostridium butyricum capsule combined with itopride can effectively relieve the digestive tract symptoms of FD patients, improve the gastrointestinal peristalsis function and clinical efficacy, which is beneficial to improving the quality of life of FD patients. It has a certain value of clinical promotion.

参考文献/References

1 Ford AC, Mahadeva S, Carbone MF, et al. Functional dyspepsia[J]. Lancet, 2020, 396(10263): 1689-1702.
2 张颖, 刘海英, 孙琳林, 等. 精神心理因素干预功能性消化不良的研究进展[J]. 实用临床医药杂志, 2022, 26(6): 123-127.
3Mounsey A, Barzin A, Rietz A. Functional dyspepsia: evaluation and management[J]. Am Fam Physician, 2020, 101(2): 84-88.
4 张雯, 陈新波. 匹维溴铵、伊托必利与多潘立酮治疗功能性消化不良的效果和用药安全性[J]. 中国老年学杂志, 2022, 42(11):2699-2701.
5Hiyama T, Yoshihara M, Tanaka S, et al. Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract[J]. J Gastroenterol Hepatol, 2009, 24(4): 537-546.
6 刘岩红, 袁凤云, 蒋立会. 酪酸梭菌活菌胶囊对行早期肠内营养支持的感染性休克患者胃肠道症状改善作用观察[J]. 中国微生态学杂志, 2021, 33(2): 209-213.
7 中华医学会消化病学分会胃肠动力学组. 中国消化不良的诊治指南（2007，大连）[J]. 中华消化杂志, 2007, 27(12): 832-834.
8Smeets FGM, Keszthelyi D, Vork L, et al. Development of a real-time patient-reported outcome measure for symptom assessment in patients with functional dyspepsia using the experience sampling method[J]. Neurogastroenterol Motil, 2019, 31(2): e13496.
9 谢渭根, 吕柏军, 李薇薇, 等. 精神心理因素与老年功能性消化不良的相关性及对患者ADL评分的影响[J]. 世界华人消化杂志, 2018, 26(34): 2002-2007.
10 Talley NJ. Functional dyspepsia: advances in diagnosis and therapy[J]. Gut Liver, 2017, 11(3): 349-357.
11 刘迎飞, 魏子白, 杨长青. 胃食管反流病重叠功能性消化不良的研究进展[J]. 国际消化病杂志, 2020, 40(5): 287-290.
12 Huang X, Lv B, Zhang S, et al. Itopride therapy for functional dyspepsia: a meta-analysis[J]. World J Gastroenterol, 2012, 18(48):7371-7377.
13 王永革, 魏华. 伊托必利与多潘立酮和行为治疗对FD患者胃肠功能治疗效果的研究[J]. 医药论坛杂志, 2014, 35(8): 142-143.
14 李文忠. 酪酸梭菌活菌胶囊联合匹维溴铵治疗腹泻型肠易激综合征临床效用观察[J]. 临床医药文献电子杂志, 2020, 7(36): 129.
15 Khoo J, Rayner CK, Feinle-Bisset C, et al. Gastrointestinal hormonal dysfunction in gastroparesis and functional dyspepsia[J]. Neurogastroenterol Motil, 2010, 22(12): 1270-1278.
16 Wang P, Zhang YJ, Li YR, et al. A correlation between gastrointestinal dysfunction and cirrhosis severity[J]. Medicine (Baltimore), 2018, 97(37): e12070.
17 Coates MD, Tekin I, Vrana KE, et al. Review article: the many potential roles of intestinal serotonin (5-hydroxytryptamine, 5-HT) signalling in inflammatory bowel disease[J]. Aliment Pharmacol Ther, 2017, 46(6): 569-580.
18 Rehfeld JF. Gastrin and the moderate hypergastrinemias[J]. Int J Mol Sci, 2021, 22(13): 6977.
19 Deloose E, Verbeure W, Depoortere I, et al. Motilin: from gastric motility stimulation to hunger signaling[J]. Nat Rev Endocrinol, 2019, 15(4): 238-250.

备注/Memo

备注/Memo:

通信作者：谢菲，Email: xf1779171fei@163.com

常用功能

更新日期/Last Update: 2024-06-25