索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]王莹,常江,杨玄,等.雌激素及其受体对肠易激综合征影响的研究进展[J].国际消化病杂志,2023,06:359-363，393.
点击复制

雌激素及其受体对肠易激综合征影响的研究进展(PDF)

《国际消化病杂志》[ISSN:1673-534X/CN:31-1953/R]

期数:
2023年06期
页码:
359-363，393
栏目:
综述
出版日期:
2023-12-30

文章信息/Info

Title:
-
作者:
王莹; 常江; 杨玄; 余荻; 徐声润
650106 昆明医科大学第二附属医院消化内科
Author(s):
-
关键词:
肠易激综合征; 雌激素; 雌激素受体; 脑-肠轴
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-534X.2023.06.001
文献标识码:
-
摘要:
肠易激综合征（IBS）是临床常见的功能性肠病，其发病机制为多种因素共同作用而引起的脑-肠互动异常。研究表明女性的IBS发病率高于男性，雌激素及其受体可通过多种中枢及外周途径参与脑-肠互动，从而导致IBS患者的性别差异。该文就雌激素及其受体对IBS影响的研究进展作一综述，以期为IBS患者的诊断和个体化治疗提供新的思路。
Abstract:
-

参考文献/References

1Oka P, Parr H, Barberio B, et al. Global prevalence of irritable bowel syndrome according to RomeⅢ or Ⅳ criteria: a systematic review and meta-analysis[J]. Lancet Gastroenterol Hepatol, 2020, 5(10):908-917.
2 中华医学会消化病学分会胃肠功能性疾病协作组, 中华医学会消化病学分会胃肠动力学组. 2020年中国肠易激综合征专家共识意见[J]. 中华消化杂志, 2020, 40(12): 803-818.
3Liu JYH, Lin G, Fang M, et al. Localization of estrogen receptor ERα,?ERβ?and?GPR30?on?myenteric?neurons?of?the?gastrointestinal?tract and their role in motility[J]. Gen Comp Endocrinol, 2019, 272:63-75.
4Sperber AD, Dumitrascu D, Fukudo S, et al. The global prevalence of IBS in adults remains elusive due to the heterogeneity of studies:a Rome Foundation working team literature review[J]. Gut, 2017, 66(6): 1075-1082.
5Weaver KR, Boulineaux CM, Robinson JM, et al. Sex hormones, BDNF,?leptin,?and?TGF-β1?in?females?with?IBS:?a?pilot?investigation[J]. Biol Res Nurs, 2021, 23(2): 231-237.
6Jacenik D, Cygankiewicz AI, Fichna J, et al. Estrogen signaling deregulation related with local immune response modulation in irritable bowel syndrome[J]. Mol Cell Endocrinol, 2018, 471: 89-96.
7Pati GK, Kar C, Narayan J, et al. Irritable bowel syndrome and the menstrual cycle[J]. Cureus, 2021, 13(1): e12692.
8Lenhart A, Naliboff B, Shih W, et al. Postmenopausal women with irritable bowel syndrome (IBS) have more severe symptoms than premenopausal women with IBS[J]. Neurogastroenterol Motil, 2020, 32(10): e13913.
9Jalili M, Hekmatdoost A, Vahedi H, et al. Co-administration of soy isoflavones and vitamin D in management of irritable bowel disease[J]. PLoS One, 2016, 11(8): e0158545.
10 Nisticò V, Rossi RE, D'Arrigo AM, et al. Functional neuroimaging in irritable bowel syndrome: a systematic review highlights common brain alterations with functional movement disorders[J]. J Neurogastroenterol Motil, 2022, 28(2): 185-203.
11 Ford AC, Lacy BE, Talley NJ. Irritable bowel syndrome[J]. N Engl J Med, 2017, 376(26): 2566-2578.
12 Labus JS, Dinov ID, Jiang Z, et al. Irritable bowel syndrome in female patients is associated with alterations in structural brain networks[J]. Pain, 2014, 155(1): 137-149.
13 Hubbard CS, Karpowicz JM, Furman AJ, et al. Estrogen-dependent visceral hypersensitivity following stress in rats: An fMRI study[J]. Mol Pain, 2016, 12: 1744806916654145.
14 Chen J, Li Q, Saliuk G, et al. Estrogen and serotonin enhance stress-induced visceral hypersensitivity in female rats by up-regulating brain-derived neurotrophic factor in spinal cord[J]. Neurogastroenterol Motil, 2021, 33(10): e14117.
15 Scharfman HE, MacLusky NJ. Differential regulation of BDNF, synaptic plasticity and sprouting in the hippocampal mossy fiber pathway of male and female rats[J]. Neuropharmacology, 2014, 76 Pt C(0 0): 696-708.
16 Ji Y, Hu B, Li J, et al. Opposing roles of estradiol and testosterone on stress-induced visceral hypersensitivity in rats[J]. J Pain, 2018, 19(7):764-776.
17 Lee JY, Choi HY, Ju BG, et al. Estrogen alleviates neuropathic pain induced after spinal cord injury by inhibiting microglia and astrocyte activation[J]. Biochim Biophys Acta Mol Basis Dis, 2018, 1864(7):2472-2480.
18 Kaur S, Hickman TM, Lopez-Ramirez A, et al. Estrogen modulation of the pronociceptive effects of serotonin on female rat trigeminal sensory neurons is timing dependent and dosage dependent and requires estrogen receptor alpha[J]. Pain, 2022, 163(8): e899-e916.
19 Hernández-Hernández OT, Martínez-Mota L, Herrera-Pérez JJ, et al. Role of estradiol in the expression of genes involved in serotonin neurotransmission: implications for female depression[J]. Curr Neuropharmacol, 2019, 17(5): 459-471.
20 Drossman DA, Chang L, Bellamy N, et al. Severity in irritable bowel syndrome: a Rome Foundation Working Team report[J]. Am J Gastroenterol, 2011, 106(10): 1749-1759, quiz 1760.
21 Lu CL, Hsieh JC, Dun NJ, et al. Estrogen rapidly modulates 5-hydroxytrytophan-induced visceral hypersensitivity via GPR30 in rats[J]. Gastroenterology, 2009, 137(3): 1040-1050.
22 Du Q, Liao Q, Chen C, et al. The role of transient receptor potential vanilloid 1 in common diseases of the digestive tract and the cardiovascular and respiratory system[J]. Front Physiol, 2019, 10: 1064.
23 Camilleri M. Sex as a biological variable in irritable bowel syndrome[J]. Neurogastroenterol Motil, 2020, 32(7): e13802.
24 Payrits M, Sághy ?, Cseko K, et al. Estradiol sensitizes the transient receptor potential vanilloid 1 receptor in pain responses[J]. Endocrinology, 2017, 158(10): 3249-3258.
25 Zhang W, Wu H, Xu Q, et al. Estrogen modulation of pain perception with?a?novel?17β-estradiol?pretreatment?regime?in?ovariectomized?rats[J]. Biol Sex Differ, 2020, 11(1): 2.
26 Zielińska M, Fichna J, Bashashati M, et al. G protein-coupled estrogen receptor and estrogen receptor ligands regulate colonic motility and visceral pain[J]. Neurogastroenterol Motil, 2017, 29(7):e13025.
27 Sun LH, Zhang WX, Xu Q, et al. Estrogen modulation of visceral pain[J]. J Zhejiang Univ Sci B, 2019, 20(8): 628-636.
28 Enck P, Azpiroz F, Boeckxstaens G, et al. Functional dyspepsia[J]. Nat Rev Dis Primers, 2017, 3: 17081.
29 Balasuriya GK, Nugapitiya SS, Hill-Yardin EL, et al. Nitric oxide regulates estrus cycle dependent colonic motility in mice[J]. Front Neurosci, 2021, 15: 647555.
30 Al-Shboul OA, Nazzal MS, Mustafa AG, et al. Estrogen relaxes gastric muscle cells via a nitric oxide- and cyclic guanosine monophosphate-dependent mechanism: A sex-associated differential effect[J]. Exp Ther Med, 2018, 16(3): 1685-1692.
31 Shah SC, Khalili H, Gower-Rousseau C, et al. Sex-based differences in incidence of inflammatory bowel diseases-pooled analysis of population-based studies from western countries[J]. Gastroenterology, 2018, 155(4): 1079-1089. e3.
32 尹相杰, 李昆明, 段涛. 妊娠期黄体分泌激素的变化及其临床意义[J]. 中国实用妇科与产科杂志, 2021, 37(4): 414-417.
33 Br?nn E, Edvinsson ?, Rostedt Punga A, et al. Inflammatory and anti-inflammatory?markers?in?plasma:?from?late?pregnancy?to?early?postpartum[J]. Sci Rep, 2019, 9(1): 1863.
34 Goodman WA, Havran HL, Quereshy HA, et al. Estrogen receptor α?loss-of-function?protects?female?mice?from?DSS-induced?experimental colitis[J]. Cell Mol Gastroenterol Hepatol, 2017, 5(4):630-633. e1.
35 Goodman WA, Bedoyan SM, Havran HL, et al. Impaired estrogen signaling underlies regulatory T cell loss-of-function in the chronically?inflamed?intestine[J].?Proc?Natl?Acad?Sci?U?S?A,?2020,?117(29): 17166-17176.
36 Son HJ, Sohn SH, Kim N, et al. Effect of estradiol in an azoxymethane/dextran sulfate sodium-treated mouse model of colorectal cancer: implication for sex difference in colorectal cancer development[J]. Cancer Res Treat, 2019, 51(2): 632-648.
37 Duan R, Zhu S, Wang B, et al. Alterations of gut microbiota in patients with irritable bowel syndrome based on 16S rRNA-targeted sequencing: a systematic review[J]. Clin Transl Gastroenterol, 2019, 10(2): e00012.
38 Tetel MJ, de Vries GJ, Melcangi RC, et al. Steroids, stress and the gut microbiome-brain axis[J]. J Neuroendocrinol, 2018, 30(2): e12548.
39 Spichak S, Donoso F, Moloney GM, et al. Microbially-derived short-chain?fatty?acids?impact?astrocyte?gene?expression?in?a?sex-specific?manner[J]. Brain Behav Immun Health, 2021, 16: 100318.
40 Simrén M, Barbara G, Flint HJ, et al. Intestinal microbiota in functional bowel disorders: a Rome foundation report[J]. Gut, 2013, 62(1): 159-176.
41 Shin JH, Park YH, Sim M, et al. Serum level of sex steroid hormone is?associated?with?diversity?and?profiles?of?human?gut?microbiome[J].?Res Microbiol, 2019, 170(4-5): 192-201.
42 Zhang Z, Chen Y, Xiang L, et al. Effect of curcumin on the diversity of gut microbiota in ovariectomized rats[J]. Nutrients, 2017, 9(10):1146.
43 Shin NR, Whon TW, Bae JW. Proteobacteria: microbial signature of dysbiosis in gut microbiota[J]. Trends Biotechnol, 2015, 33(9): 496-503.
44 Menon R, Watson SE, Thomas LN, et al. Diet complexity and estrogen?receptor?β?status?affect?the?composition?of?the?murine?intestinal microbiota[J]. Appl Environ Microbiol, 2013, 79(18): 5763-5773.
45 Wu H, Chen X, Zhang S, et al. Gut microbiota, the potential biological medicine for prevention, intervention and drug sensitization?to?fight?diseases[J].?Nutrients,?2022,?14(20):?4220.
46 Takagi T, Naito Y, Inoue R, et al. Differences in gut microbiota associated with age, sex, and stool consistency in healthy Japanese subjects[J]. J Gastroenterol, 2019, 54(1): 53-63.
47 Yoon K, Kim N. Roles of sex hormones and gender in the gut microbiota[J]. J Neurogastroenterol Motil, 2021, 27(3): 314-325.
48 Kaliannan K, Robertson RC, Murphy K, et al. Estrogen-mediated gut microbiome alterations influence sexual dimorphism in metabolic syndrome in mice[J]. Microbiome, 2018, 6(1): 205.
49 Vicentini FA, Keenan CM, Wallace LE, et al. Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia[J]. Microbiome, 2021, 9(1): 210.
50 Zeibich L, Koebele SV, Bernaud VE, et al. Surgical menopause and estrogen therapy modulate the gut microbiota, obesity markers, and spatial memory in rats[J]. Front Cell Infect Microbiol, 2021, 11:702628.

备注/Memo

备注/Memo:
通信作者：常江，Email: cjcjchangjiang@sina.com
更新日期/Last Update: 1900-01-01