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《国际消化病杂志》[ISSN:1673-534X/CN:31-1953/R]

期数:

2023年06期

页码:

371-375

栏目:

论著

出版日期:

2023-12-30

文章信息/Info

Title:

Expression and prognostic predictive value of circRNA FN1 in esophageal cancer tissues

作者:

韩晓锐; 陈小芳

710100 西安国际医学中心医院病理科

Author(s):

HAN Xiaorui;  CHEN Xiaofang.

Department of Pathology, Xi'an International Medical Center Hospital, Xi'an 710100, China

关键词:

食管癌; 癌组织; 环状RNA ; 预后预测

Keywords:

Esophageal cancer;  Cancer tissue;  Circular RNA;  Prognosis

分类号:

-

DOI:

10.3969/j.issn.1673-534X.2023.06.004

文献标识码:

-

摘要:

目的探究环状RNA纤维连接蛋白1（circRNAFN1，下文简称FN1）在食管癌组织中的表达水平，分析其与食管癌患者临床病理特征的关系和预后预测价值。方法选择2015年1月至2017年1月在西安国际医学中心医院和西安高新医院接受食管癌切除术的115例食管癌患者，收集患者的食管癌组织和癌旁组织，术后随访60个月。采用实时荧光定量PCR法检测食管癌组织及癌旁组织中FN1的表达水平，采用Kaplan-Meier法分析食管癌组织中FN1的表达水平与患者预后的关系，采用Cox回归模型分析食管癌患者预后的独立危险因素。结果食管癌组织中FN1的相对表达量为2.88±0.63，显著高于癌旁组织（1.02±0.02），差异有统计学意义（t＝11.293，P＝0.001）。FN1高表达组与FN1低表达组的性别、年龄、肿瘤浸润深度差异均无统计学意义（P均＞0.05），2组的淋巴结转移、肿瘤直径、临床分期差异均有统计学意义（P均＜0.05）。Kaplan-Meier生存分析结果显示，FN1高表达组的累积生存率显著低于FN1低表达组，差异有统计学意义（P＝0.047）。单因素Cox回归模型分析结果显示，食管癌患者的预后与淋巴结转移、肿瘤直径、临床分期及食管癌组织中FN1表达水平均有相关性（P均＜0.05）。多因素Cox回归模型分析结果显示，淋巴结转移、临床分期、食管癌组织中FN1表达水平均为食管癌患者预后的独立危险因素（P均＜0.05）。结论食管癌组织中FN1表达上调，其可作为预测食管癌患者预后的生物标志物。

Abstract:

Objective? This paper attempts to investigate the expression of circle RNA fibronectin 1 (circRNA FN1, hereinafter referred to as FN1) in esophageal cancer tissues and to analyze its relationship with clinicopathological features and prognostic predictive value in patients with esophageal cancer. Methods? A total of 115 esophageal cancer patients who underwent esophagectomy for esophageal cancer at Xi'an International Medical Center Hospital and Xi'an Gaoxin Hospital from January 2015 to January 2017 were selected, whose esophageal cancer tissues and paracancerous tissues were collected and followed up for 60 months after surgery. The expression of FN1 in esophageal cancer tissues and paracancerous tissues was detected by real-time fluorescence quantitative PCR, the relationship between the expression level of FN1 in esophageal cancer tissues and patients' prognosis was analyzed utilizing the Kaplan-Meier method, and the independent risk factors for the prognosis of esophageal cancer patients were analyzed using the Cox regression model. Results? The relative expression of FN1 in esophageal cancer tissues is 2.88±0.63, which is significantly higher than that in paraneoplastic tissues (1.02±0.02), with a statistically significant difference (t＝11.293, P＝0.001). The differences in gender, age, and depth of tumor infiltration between the FN1 high-expression group and the FN1-low-expression group are not statistically significant (P＞0.05), and the differences between the 2 groups in lymph node metastasis, tumor diameter, and clinical stage are statistically significant (P＜0.05). The results of Kaplan-Meier survival analysis show that the cumulative survival rate of the FN1 high-expression group is significantly lower than that of the FN1 low-expression group, with a statistically significant difference (P＝0.047). The results of one-way Cox regression model analysis show that the prognosis of esophageal cancer patients is related to lymph node metastasis, tumor diameter, clinical stage, and the FN1 expression in esophageal cancer tissues (P＜0.05). The results of multifactorial Cox regression model analysis show that lymph node metastasis, clinical stage, and the FN1 expression in esophageal cancer tissues are all independent risk factors for the prognosis of esophageal cancer patients (P＜0.05). Conclusion? FN1 expression is upregulated in esophageal cancer tissues, which can be used as a biomarker for prognostic prediction in esophageal cancer patients.

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备注/Memo

备注/Memo:

通信作者：陈小芳，Email: chenxiaofang122@126.com

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更新日期/Last Update: 1900-01-01