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[1]胡亚朋,袁春銮.Spondin-2在肝细胞癌组织中的表达及对预后的预测价值[J].国际消化病杂志,2023,06:401-406.
　HU Yapeng,YUAN Chunluan..Expression of Spondin-2 in hepatocellular carcinoma and its prognostic value[J].International Journal of Digestive Disease,2023,06:401-406.
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Spondin-2在肝细胞癌组织中的表达及对预后的预测价值(PDF)

《国际消化病杂志》[ISSN:1673-534X/CN:31-1953/R]

期数:
2023年06期
页码:
401-406
栏目:
论著
出版日期:
2023-12-30

文章信息/Info

Title:
Expression of Spondin-2 in hepatocellular carcinoma and its prognostic value
作者:
胡亚朋; 袁春銮
222000 连云港市第一人民医院肿瘤科
Author(s):
HU Yapeng;  YUAN Chunluan.
Department of Oncology, the First People's Hospital of Lianyungang, Lianyungang 222000, China
关键词:
脊椎蛋白-2; 肝细胞癌; 预后; 预测价值
Keywords:
Spondin-2;  Hepatocellular carcinoma;  Prognosis;  Predictive value
分类号:
-
DOI:
10.3969/j.issn.1673-534X.2022.06.009
文献标识码:
-
摘要:
目的探讨脊椎蛋白-2（Spondin-2）在肝细胞癌（HCC）组织中的表达及对患者预后的预测价值。方法选择2019年5月至2020年1月连云港市第一人民医院收治的89例HCC患者作为研究对象，患者均接受HCC根治术，术后随访3年。术中采集入组患者的HCC组织和癌旁组织，采用免疫组织化学法检测组织中Spondin-2的表达水平，并分析HCC组织中Spondin-2的表达与患者临床病理特征的关系。采用Kaplan-Meier法绘制生存曲线，以log-rank检验分析HCC组织中Spondin-2的表达与患者无瘤生存率的关系。采用Cox比例风险回归模型分析影响HCC患者复发的因素。结果HCC组织中Spondin-2的阳性表达率显著高于癌旁组织（82.02%比51.69%），差异有统计学意义（P＜0.001）。低分化、肿瘤包膜不完整、TNM分期Ⅲ期、有微血管侵犯者的HCC组织中Spondin-2的阳性表达率分别高于中高分化、肿瘤包膜完整、TNM分期Ⅰ～Ⅱ期、无微血管侵犯者，组间差异均有统计学意义（P均＜0.05）。多因素Cox回归模型分析结果显示，肿瘤包膜完整性、分化程度、微血管侵犯、TNM分期和Spondin-2均是影响HCC患者术后复发的独立危险因素（P均＜0.05）。随访结果显示，89例HCC患者中有7例失访，在其余82例患者中，Spondin-2阴性表达者（14例）中有12例无瘤生存，Spondin-2阳性表达者（68例）中有27例无瘤生存。Kaplan-Meier生存曲线分析结果显示，Spondin-2阳性表达者的无瘤生存率（39.71%）显著低于Spondin-2阴性表达者（85.71%），2组的差异有统计学意义（log-rankχ2＝5.355，P＝0.021）。结论HCC组织中Spondin-2的表达与患者临床病理特征及预后均密切相关，且Spondin-2阳性表达者的预后不良风险较高。
Abstract:
Objective? An attempt is made in this paper to investigate the expression of Spondin-2 in hepatocellular carcinoma (HCC) and its prognostic value. Methods? A total of 89 HCC patients admitted to the First People's Hospital of Lianyungang between May 2019 to January 2020 were selected, who received radical resection of HCC and were followed up for 3 years. During the operation, HCC tissues and adjacent tissues of enrolled patients were collected, and the expression of Spondin-2 in HCC tissues was determined by immunohistochemistry, and the relationship between the expression of Spondin-2 in HCC tissues and the clinicopathological features of patients was analyzed. The Kaplan-Meier method was used to draw the survival curve, and the log-rank test was used to analyze the relationship between Spondin-2 expression in HCC tissues and the tumor-free survival rate of patients. The Cox proportional risk regression model was used to analyze the factors affecting relapse in HCC patients. Results? The positive expression rate of Spondin-2 in HCC tissues is higher than that in paracancer tissues (82.02% versus 51.69%), with a statistically significant difference (P＜0.001). The positive expression rate of Spondin-2 in HCC tissues of poorly differentiated, incomplete tumor envelope, TNM stage Ⅲ, and microvascular invasion is higher than that of medium to high differentiated, intact tumor envelope, TNM stage ⅠtoⅡ, and no microvascular invasion, respectively, with statistically significant differences (P＜0.05). The multivariate Cox regression analysis shows that tumor envelope integrity, degree of differentiation, microvascular invasion, TNM stage, and Spondin-2 are independent risk factors for postoperative recurrence in HCC patients (P＜0.05). The follow-up results show that 7 out of 89 HCC patients are lost to follow-up, and among the remaining 82 patients, 12 out of 14 patients with negative expression of Spondin-2 and 27 out of 68 patients with positive expression of Spondin-2 survive without tumors. The Kaplan-Meier survival curve analysis shows that the tumor-free survival rate of Spondin-2 positive expression group (39.71%) is lower than that of Spondin-2 negative expression group (85.71%), with a statistically significant difference (log-rank χ2＝5.355 and P＝0.021). Conclusion? The expression of Spondin-2 in HCC tissues is closely related to the clinicopathological features and prognosis of patients, and the patients with positive expression of Spondin-2 have a higher risk of poor prognosis.

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备注/Memo

备注/Memo:
通信作者：袁春銮，Email: yuancla@163.com
更新日期/Last Update: 1900-01-01