索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]陈俊杰,杨长青,魏子白.内脏高敏感在肠易激综合征中的研究进展[J].国际消化病杂志,2017,05:274-277.
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内脏高敏感在肠易激综合征中的研究进展(PDF)

《国际消化病杂志》[ISSN:1673-534X/CN:31-1953/R]

期数:
2017年05期
页码:
274-277
栏目:
综述
出版日期:
2017-09-20

文章信息/Info

Title:
-
作者:
陈俊杰; 杨长青; 魏子白
046000 长治医学院附属和平医院消化科
Author(s):
-
关键词:
肠易激综合征;  内脏高敏感;  肠道菌群
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-534X.2017.05.002
文献标识码:
A
摘要:
肠易激综合征患者的内脏高敏感发生机制尚未明确,通常认为可能与受体及通道的异常改变、神经递质的改变、肠道菌群的失调等多种因素有关。近年来大量研究发现,大麻素受体、瞬时受体电位香草酸受体1、5-羟色胺及其受体、囊泡谷氨酸转运体、肠道菌群紊乱以及钠离子通道在内脏高敏感的发生中起重要作用。此文就近年来有关内脏高敏感发生机制的研究进展作一综述。
Abstract:
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参考文献/References

1 Torpy JM, Golub RM. JAMA patient page. Irritable bowel syndrome[J]. JAMA, 2011, 306: 1501.
2 Shen L, Yang X, Qian W, et al. The role of peripheral cannabinoid receptors type 1 in rats with visceral hypersensitivity induced by chronic restraint stress[J]. J Neurogastroenterol Motil, 2010, 16: 281-290.
3 Fichna J, Sibaev A, Saaga M, et al. The cannabinoid-1 receptor inverse agonist taranabant reduces abdominal pain and increases intestinal transit in mice[J]. Neurogastroenterol Motil, 2013, 25: e550-e559.
4 Jiang Y, Nie Y, Li Y, et al. Association of cannabinoid type 1 receptor and fatty acid amide hydrolase genetic polymorphisms in Chinese patients with irritable bowel syndrome[J]. J Gastroenterol Hepatol, 2014, 29: 1186-1191.
5 Wong BS, Camilleri M, Busciglio I, et al. Pharmacogenetic trial of a cannabinoid agonist shows reduced fasting colonic motility in patients with nonconstipated irritable bowel syndrome[J]. Gastroenterology, 2011, 141: 1638-1647. e7.
6 Cremon C, Stanghellini V, Barbaro MR, et al. Randomised clinical trial: the analgesic properties of dietary supplementation with palmitoylethanolamide and polydatin in irritable bowel syndrome[J]. Aliment Pharmacol Ther, 2017, 45: 909-922.
7 Iwata Y, Ando K, Taniguchi K, et al. Identification of a highly potent and selective CB2 agonist, RQ-00202730, for the treatment of irritable bowel syndrome[J]. Bioorg Med Chem Lett, 2015, 25: 236-240.
8 Akbar A, Yiangou Y, Facer P, et al. Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain[J]. Gut, 2008, 57: 923-929.
9 Zhou Q, Yang L, Larson S, et al. Decreased miR-199 augments visceral pain in patients with IBS through translational upregulation of TRPV1[J]. Gut, 2016, 65: 797-805.
10 Evangelista S. Novel therapeutics in the field of capsaicin and pain[J]. Expert Rev Clin Pharmacol, 2015, 8: 373-375.
11 Chen MX, Chen Y, Fu R, et al. Activation of 5-HT and NR2B contributes to visceral hypersensitivity in irritable bowel syndrome in rats[J]. Am J Transl Res, 2016, 8: 5580-5590.
12 Panteleev SS, Martseva AА, Lyubashina OА. The inhibitory effect of granisetron on ventrolateral medulla neuron responses to colorectal distension in rats[J]. Eur J Pharmacol, 2015, 749: 49-55.
13 Fukudo S, Kinoshita Y, Okumura T, et al. Ramosetron reduces symptoms of irritable bowel syndrome with diarrhea and improves quality of life in women[J]. Gastroenterology, 2016, 150: 358-366. e8.
14 Filpa V, Moro E, Protasoni M, et al. Role of glutamatergic neurotransmission in the enteric nervous system and brain-gut axis in health and disease[J]. Neuropharmacology, 2016, 111: 14-33.
15 Seal RP, Wang X, Guan Y, et al. Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors[J]. Nature, 2009, 462: 651-655.
16 Yang CQ, Duan LP, Qiao PT, et al. Increased VGLUT3 involved in visceral hyperalgesia in a rat model of irritable bowel syndrome[J]. World J Gastroenterol, 2015, 21: 2959-2966.
17 O'Mahony SM, Dinan TG, Cryan JF. The gut microbiota as a key regulator of visceral pain[J]. Pain, 2017, 158(Suppl 1): S19-S28.
18 Crouzet L, Gaultier E, Del'Homme C, et al. The hypersensitivity to colonic distension of IBS patients can be transferred to rats through their fecal microbiota[J]. Neurogastroenterol Motil, 2013, 25: e272-e282.
19 Zhou XY, Li M, Li X, et al. Visceral hypersensitive rats share common dysbiosis features with irritable bowel syndrome patients[J]. World J Gastroenterol, 2016, 22: 5211-5227.
20 Moraes-Filho JP, Quigley EM. The intestinal microbiota and the role of probiotics in irritable bowel syndrome: a review[J]. Arq Gastroenterol, 2015, 52: 331-338.
21 Eutamene H, Lamine F, Chabo C, et al. Synergy between Lactobacillus paracasei and its bacterial products to counteract stress-induced gut permeability and sensitivity increase in rats[J]. J Nutr, 2007, 137: 1901-1907.
22 Xu D, Gao J, Gillilland M, et al. Rifaximin alters intestinal bacteria and prevents stress-induced gut inflammation and visceral hyperalgesia in rats[J]. Gastroenterology, 2014, 146: 484-496. e4.
23 Dupont HL. Review article: evidence for the role of gut microbiota in irritable bowel syndrome and its potential influence on therapeutic targets[J]. Aliment Pharmacol Ther, 2014, 39: 1033-1042.
24 Perez-Burgos A, Wang L, McVey Neufeld KA, et al. The TRPV1 channel in rodents is a major target for antinociceptive effect of the probiotic Lactobacillus reuteri DSM 17938[J]. J Physiol, 2015, 593: 3943-3957.
25 邵珲, 王进海, 张杰, 等. 肠道菌群失调对内脏敏感性的影响及其机制[J]. 西安交通大学学报(医学版), 2015, 6: 758-764, 781.
26 Tana C, Umesaki Y, Imaoka A, et al. Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome[J]. Neurogastroenterol Motil, 2010, 22: 512-519. e114-e115.
27 Xu GY, Winston JH, Shenoy M, et al. The endogenous hydrogen sulfide producing enzyme cystathionine-β synthase contributes to visceral hypersensitivity in a rat model of irritable bowel syndrome[J]. Molecular pain, 2009, 5: 44.
28 Beyder A, Mazzone A, Strege PR, et al. Loss-of-function of the voltage-gated sodium channel NaV 1.5(channelopathies)in patients with irritable bowel syndrome[J]. Gastroenterology, 2014, 146: 1659-1668.
29 Campaniello MA, Harrington AM, Martin CM, et al. Activation of colo-rectal high-threshold afferent nerves by Interleukin-2 is tetrodotoxin-sensitive and upregulated in a mouse model of chronic visceral hypersensitivity[J]. Neurogastroenterol Motil, 2016, 28: 54-63.
30 Hu S, Xiao Y, Zhu L, et al. Neonatal maternal deprivation sensitizes voltage-gated sodium channel currents in colon-specific dorsal root ganglion neurons in rats[J]. Am J Physiol Gastrointest Liver Physiol, 2013, 304: G311-G321.
31 Leo S, D'Hooge R, Meert T. Exploring the role of nociceptor-specific sodium channels in pain transmission using Nav 1.8 and Nav 1.9 knockout mice[J]. Behav Brain Res, 2010, 208: 149-157.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81600422) 通信作者:魏子白,Email: weizibai@sohu.com
更新日期/Last Update: 2017-09-20