|本期目录/Table of Contents|

[1]王 琼,吕 颖.IL-35和IL-37在幽门螺杆菌相关性胃炎和胃溃疡患者中的表达及临床意义[J].国际消化病杂志,2023,06:376-380.
　WANG QiongLYU Ying.Expression and clinical significance of IL-35 and IL-37 in Helicobacter pylori-associated gastritis and gastric ulcer patients[J].International Journal of Digestive Disease,2023,06:376-380.
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IL-35和IL-37在幽门螺杆菌相关性胃炎和胃溃疡患者中的表达及临床意义(PDF)

《国际消化病杂志》[ISSN:1673-534X/CN:31-1953/R]

期数:
2023年06期
页码:
376-380
栏目:
论著
出版日期:
2023-12-30

文章信息/Info

Title:
Expression and clinical significance of IL-35 and IL-37 in Helicobacter pylori-associated gastritis and gastric ulcer patients
作者:
王 琼; 吕 颖
810007 青海西宁，中国人民解放军联勤保障部队第九四一医院检验输血科（王琼），五官科（吕颖）
Author(s):
WANG Qiong; LYU Ying
WANG Qiong. Department of Examination the Blood Transfusion, No. 941 Hospital, Joint Support Force of the Chinese People's Liberation Army, Xining 810007, China;LYU Ying. Department of Facial Features, No. 941 Hospital, Joint Support Force of the Chinese People's Liberation Army, Xining 810007, China
关键词:
幽门螺杆菌; 胃炎; 胃溃疡; IL-35 ; IL-37
Keywords:
Helicobacter pylori;  Gastritis;  Gastric ulcer;  IL-35;  IL-37
分类号:
-
DOI:
10.3969/j.issn.1673-534X.2023.06.005
文献标识码:
-
摘要:
目的探究IL-35和IL-37在幽门螺杆菌（Hp）相关性胃炎和胃溃疡患者中表达水平的差异。方法选择2019年6月至2021年6月中国人民解放军联勤保障部队第九四一医院收治的胃炎和胃溃疡患者作为研究对象。经纳入、排除标准筛选，共入组124例患者，其中Hp相关性胃炎患者42例（设为HAG组），非Hp相关性胃炎患者24例（设为nHAG组），Hp相关性胃溃疡患者38例（设为HGU组），非Hp相关性胃溃疡患者20例（设为nHGU组）。采用ELISA法检测血浆中IL-35和IL-37蛋白的表达水平。采用实时荧光定量PCR法检测胃黏膜组织中IL-35和IL-37mRNA的表达水平。采用logistic回归模型分析影响Hp相关性胃溃疡发生的危险因素。结果与nHAG组相比，HAG组血浆中IL-35和IL-37蛋白的表达水平，以及胃黏膜组织中IL-35和IL-37mRNA的相对表达量均显著降低（P均＜0.05）。与nHGU组相比，HGU组血浆中IL-35和IL-37蛋白的表达水平，以及胃黏膜组织中IL-35和IL-37mRNA的相对表达量均显著降低（P均＜0.05）。Hp相关性胃溃疡患者血浆中IL-37蛋白的表达水平，以及胃黏膜组织中IL-35和IL-37mRNA的相对表达量均与胃溃疡的发生呈负相关，且均为胃溃疡发生的保护因素（P均＜0.05）。结论Hp相关性胃炎和胃溃疡患者中IL-35和IL-37均呈低表达，两者对于诊断胃炎和胃溃疡患者是否感染Hp具有一定应用价值。
Abstract:
Objective? This paper is to investigate the differences in IL-35 and IL-37 expressions in Helicobacter pylori (Hp)-associated gastritis and gastric ulcer patients. Methods? Patients with gastritis and gastric ulcer admitted to the No. 941 Hospital of Joint Support Force of the Chinese People's Liberation Army between June 2019 and June 2021 were selected as the study subjects, and 124 patients were enrolled after screening according to the inclusion and exclusion criteria, including 42 patients with Hp-associated gastritis (HAG group), 24 patients with non-Hp-associated gastritis (nHAG group), 38 patients with Hp-associated gastric ulcer (HGU group), and 20 patients with non-Hp-associated gastric ulcer (nHGU group). The expression of IL-35 and IL-37 protein in plasma were detected by ELISA, and the expression of IL-35 and IL-37 mRNA in gastric mucosa were detected by real-time fluorescence quantitative PCR. The risk factors of Hp-related gastric ulcer were analyzed by logistic regression model. Results Compared with the nHAG group, the expression of IL-35 and IL-37 in plasma and the relative expression of IL-35 and IL-37 mRNA in gastric mucosa in the HAG group are decreased, with a statistically significant difference (P＜0.05). Compared with the nHGU group, the expression of IL-35 and IL-37 in plasma and the relative expression of IL-35 and IL-37 mRNA in gastric mucosa in the HGU group are decreased, with a statistically significant difference (P＜0.05). The expression of IL-37 protein in plasma and the relative expression of IL-35 and IL-37 mRNA in gastric mucosa of patients with Hp-related gastric ulcer are negatively correlated with the occurrence of gastric ulcer, and are protective factors of gastric ulcer (P＜0.05). Conclusion The expression of IL-35 and IL-37 are low in patients with Hp-related gastritis and gastric ulcer, both of which have a certain application value in distinguishing whether patients with gastritis and gastric ulcer are infected with Hp.

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备注/Memo

备注/Memo:
-
更新日期/Last Update: 1900-01-01